TOC Question and answer toc full form

TOC Question and answer

 

What is the full form of TOC?

TOC total organic carbon

what is use of TOC analyzers in pharmaceutical industry?

A total organic carbon analyzers also referred to as TOC analyzers measures the amount of

total organic carbon present in a liquid or a water sample.

 

What higher TOC count indicates or why we should control TOC count?

An increase in TOC indicates the introduction of organic contaminants such as microbial byproducts residue from cleaning agents or degradation products from materials.

 

What is TOC limit for water for injection?

The total organic carbon or TOC limit for water for injection that is WFI as per United States

pharmacopeia that is USP is not to exceed 500 parts per billion or PPP.

This specification can be found in USP chapter number 1, 2, 3, 1, tightened as water for

pharmaceutical purposes.

 

What are the methods to introduce sample into TOC analyzer?

There are mainly 5 methods to introduce sample into TOC analyzer.

These are direct injection auto sampler, continuous flow, manual injection and sample

combustion.

 

What is difference between online and offline TOC analysis?

The basic difference is in integration.

Online TOC analysis is done integrated directly into the process or system, whereas offline

TOC analysis is conducted separately from the process or system.

In case of online TOC analysis, it is continuous and real time within the process and no sample

collection or preparation is required.

In case of offline TOC analysis, this is conducted in a lab and requires sample collection

transportation and preparation.

 

How TOC analyzer works?

TOC analyzer is including a portable TOC analyzer utilizing the same basic technique.

There are 5 major steps of TOC analyzer working.

Step number 1, sample preparation.

In this step, acid is added to the liquid sample to remove the inorganic carbon that

is IC.

Second step, IC conversion.

In this step, the added acid converts the inorganic carbon into carbon dioxide gas.

Step 3, gas removal.

In this step, the carbon dioxide gas is stripped out or removed of the liquid by a carrier

gas.

Step 4, organic carbon oxidation.

In this step, the remaining inorganic carbon free sample undergoes oxidation and fifth important

last step is TOC measurement.

In this step, the carbon dioxide gas generated from the oxidation process is directly related

to the total organic carbon that is TOC in the sample.

 

How does TOC analysis used in cleaning validation in the pharmaceutical industry?

TOC analysis is used to verify the removal of organic residues from the equipment surfaces

after cleaning procedures, ensuring that no harmful contaminants remain that could compromise

product quality or patient safety.

 

What are the major components of TOC analyzer?

Sample introduction system, oxidation reactor, detection system and data acquisition and

processing system are the major components of TOC analyzer.

 

Why it is important to measure TOC in pharmaceutical industry?

In the pharmaceutical industry, total organic carbon, that is TOC measurement is important

for quality control, process monitoring and contaminant detection.

It ensures regulatory compliance by verifying water purity aids in cleaning variation to prevent

cross contamination and helps to optimize manufacturing processes to reduce cost and enhance efficiency.

 

What is basic difference between organic carbon and inorganic carbon?

Organic carbon contains carbon hydrogen bonds and they are derived from living organisms

by their byproducts and this can be metabolized by organisms.

In case of inorganic carbon, they lack carbon hydrogen bonds and primarily originated from

non-biological sources.

They are less reactive and often stable in the environment.

 

How TOC analyzers are calibrated?

TOC analyzers are calibrated by using standard reference material with non-concentration of

organic carbon.

These standards are typically prepared from potassium hydrogen thalid or other certified

organic compounds.

The analyzer measures the carbon content of the standards and adjusts its calibration

settings accordingly to ensure accurate TOC measurements in the sample.

 

What is working principle of TOC analyzers?

TOC refers to a total organic carbon analyzer which utilizes a catalytic oxidation combustion

technique at high temperature.

The temperature rises up to 720 degree Celsius to convert organic carbon into CO2, that is

carbon dioxide.

The carbon dioxide generated by oxidation is measured with non-dispercive infrared, that

is NDIR sensor.

 

What are the methods to reduce TOC in processing or generation of water for injection, that is WFI?

Distillation reverse osmosis that is RO, ultra filtration, UV oxidation and ozonation are

the methods to reduce TOC in the processing or generation of water for injection.

 

What is differential or TC-IC method in TOC analysis?

The differential TC-IC method in TOC analyzers involves quantifying the difference between

total carbon, that is TC, and inorganic carbon, that is IC content in a sample.

By subtracting IC from TC, the remaining organic carbon content or TOC is determined.

It is a precise technique ideal for low TOC concentration samples.

 

who are the major suppliers for the TOC analyzers worldwide?

Schimard’s Corporation has company, Metalar, Tolido, G, Analytical Instruments and Severs

are the major suppliers for the TOC analyzers worldwide.